Follow Interstate 22 for 128 miles from Tupelo, Mississippi, to Birmingham, Alabama — a modern corridor across rolling hills, Appalachian foothills, and historic U.S. 78 communities.
Tupelo
Explore Tupelo, MS—the birthplace of Elvis Presley and a city rich in history, culture, and culinary delights. Discover attractions, events, and the vibrant community that make Tupelo a must-visit destination.
Nestled in the heart of northeast Mississippi, Tupelo is a city that harmoniously blends rich history, cultural vibrancy, and modern amenities. With a 2025 estimated population of approximately 37,511, Tupelo stands as the seventh-largest city in the state and serves as the county seat of Lee County. Its strategic location along major highways and the historic Natchez Trace Parkway makes it a pivotal hub for commerce, tourism, and culture in the region.
Tupelo’s claim to fame is being the birthplace of Elvis Presley, the undisputed King of Rock ‘n’ Roll. Visitors from around the globe flock to the Elvis Presley Birthplace, a museum complex that includes the humble two-room house where Elvis was born, a chapel, and a museum chronicling his early life. Beyond Elvis, Tupelo boasts a plethora of attractions such as the Tupelo Buffalo Park & Zoo, home to over 260 animals including a herd of American bison , and the Oren Dunn City Museum, which offers insights into the city’s rich history.
The city’s vibrant downtown area is a testament to its commitment to community and culture. The Fairpark District is a lively space featuring the Cadence Bank Arena, hosting concerts and events year-round. For those seeking culinary delights, Tupelo’s food scene is a hidden gem. From the mouthwatering barbecue at Clay’s House of Pig to the innovative dishes at Forklift Restaurant, there’s something to satisfy every palate. Coffee aficionados can indulge in specialty brews at Lost + Found Coffee Company, while Queen’s Reward Meadery offers unique honey-based wines that have garnered national attention.
Experience Tupelo
Interstate 22: Birmingham to Tupelo – Alabama/Mississippi
Cruise west on Interstate 22 from Birmingham, Alabama to Tupelo, Mississippi for 128 miles of rolling hills, forested landscapes, and Southern charm. This modern corridor links the Appalachian foothills with Mississippi’s musical heartland, offering a smooth ride and …
U.S. Route 278: Tupelo to Oxford – Mississippi
Cruise across north-central Mississippi on U.S. Route 278 from Tupelo to Oxford. This 59-mile drive offers a smooth ride through wooded landscapes, small towns like Pontotoc, and ends with a scenic bypass around Oxford, home of Ole Miss.
U.S. Route 278: Oxford to Tupelo – Mississippi
Cruise 59 miles along U.S. Route 278 from Oxford to Tupelo, Mississippi. This four-lane drive offers scenic woodlands, college-town charm, access to Trace State Park, and a finish at the historic Natchez Trace Parkway near Elvis Presley’s hometown.
Natchez Trace Parkway: Tupelo – Mississippi
Cruise 7 peaceful miles along the Natchez Trace Parkway in Tupelo, Mississippi—from I-22 to US-278—exploring the serene forested corridor that skirts the city’s southwest side with access to local roads, Civil War history, and nearby Elvis landmarks.
[Revisited] Natchez Trace Parkway: Northbound through Tupelo – Mississippi
Cruise 9 peaceful miles north along the Natchez Trace Parkway through Tupelo, Mississippi, passing wooded hills, city interchanges, and the Natchez Trace Visitor Center—where nature and history meet.
Natchez Trace Parkway – Tupelo to Alabama – Mississippi
Cruise 48 miles north along the Natchez Trace Parkway from Tupelo, Mississippi to the Alabama border, taking in historic sites, scenic overlooks, and the natural beauty of Tishomingo State Park. Discover why this quiet, history-rich route is one of the South’s most be…
Northbound U.S. Route 45 in Tupelo – Mississippi
Cruise north along U.S. Highway 45 through Tupelo, Mississippi, from Main Street to I-22. Explore local interchanges, historic routes, and handy city connections in this quick drive through Elvis’s hometown.
Drive to Elvis’ Birthplace from Interstate 22 in Tupelo, Mississippi
Take a short drive from Interstate 22 in Tupelo, Mississippi, along Veterans Memorial Boulevard to Elvis Presley’s Birthplace. This easy two-mile route passes through Veterans Park and a quiet neighborhood, ending at the King’s original home and museum complex. A qu…
Interstate 22: Memphis to Tupelo – Mississippi
Cruise Interstate 22 from Byhalia near Memphis to Tupelo, Mississippi. This 76-mile drive rolls through quiet towns, the scenic Holly Springs National Forest, and the welcoming outskirts of Tupelo — blending rural charm with forested beauty.
Main Street: Westbound in Tupelo – Mississippi
Drive 4 miles west along Main Street in Tupelo, Mississippi—from Elvis Presley Dr through downtown to the Natchez Trace Parkway. Explore Tupelo’s charm, history, and scenic gateways in this short but memorable ride.
Main Street: Eastbound in Tupelo – Mississippi
Take a drive eastbound along Main Street in Tupelo, Mississippi, from the Natchez Trace Parkway to Veterans Memorial Blvd. Explore the city’s vibrant downtown, historic charm, and local culture in this 4-mile journey through the birthplace of Elvis.