Interstate 49: Pineville to Joplin – Missouri

Heading north through the hills of southwestern Missouri, Interstate 49 offers a quick but scenic route between Pineville and the city of Joplin. This 37-mile stretch begins just south of Pineville where U.S. Highway 71 officially upgrades into I-49. From here, we’re on a modern four-lane freeway that gently curves through the Ozark Plateau, with tree-covered ridges, farmland, and small-town pit stops along the way. It’s a smooth drive with limited congestion, making it ideal for both commuters and long-haul travelers heading north toward Kansas City or east-west on I-44.

Shortly after the route becomes Interstate 49, we pass the town of Anderson, tucked into the hills along Indian Creek. It’s a quiet town with some local charm and a few roadside businesses near the exit. North of Anderson, the highway continues through mostly wooded terrain as we approach Goodman, another small McDonald County community. While neither town is large, both make for decent detours if you’re after small-town Missouri vibes or a break from freeway driving.

As we continue northbound, the route enters Newton County, where the larger community of Neosho comes into view. Here, we take a brief exit at Missouri Route 86 to fuel up—a handy stop with several gas stations and fast food options just off the ramp. Neosho itself sits just a few minutes west of the interstate and offers a bit more in the way of restaurants and lodging if you’re planning a longer pause. Nicknamed the “Flower Box City,” Neosho has some charming historic architecture and a quaint downtown worth checking out if time allows.

Back on the road, the final leg of the journey takes us past Tipton Ford, a quiet community near the confluence of several rail lines. The road curves gently through the countryside as we approach the Joplin metro area from the southeast. Just before entering town, you’ll spot increasing signs of commercial development—warehouses, distribution centers, and a few manufacturing facilities mark the gateway to this former mining boomtown.

Our drive concludes at the interchange with Interstate 44, where I-49 ends its run in Joplin. From here, travelers can head east toward Springfield or west toward Tulsa. Joplin itself is a bustling regional hub with a revitalized downtown, Route 66 history, and plenty of amenities—making it a worthy destination whether you’re wrapping up your drive or just passing through.