Interstate 40 (I-40) is one of the nation’s longest and most significant east–west routes, stretching over 2,500 miles from Barstow, California, to Wilmington, North Carolina. Traversing eight states, I-40 serves as a major commercial artery and scenic cross-country corridor, paralleling historic U.S. Route 66 for much of its western half. The highway plays a critical role in both freight movement and tourism, connecting major cities including Oklahoma City, Little Rock, Memphis, Nashville, and Knoxville.

The western segment of I-40 offers travelers expansive desert landscapes and cultural landmarks, from the Mojave Desert to the Petrified Forest and Albuquerque’s high desert basin. As it moves eastward, the terrain shifts dramatically—from the high plains of Texas and rolling hills of Arkansas to the lush river valleys of Tennessee. I-40 crosses several major interstates, including I-5, I-25, I-35, I-55, and I-75, making it a vital junction point for north–south connections as well.

Notable challenges along I-40 include seasonal weather hazards, especially winter storms in the high elevations of Arizona and severe storms in the Midwest and Southeast. Despite these conditions, I-40 remains a preferred route for coast-to-coast travel due to its relatively direct alignment, robust infrastructure, and diverse roadside attractions. Whether you’re a long-haul trucker, road-tripper, or history buff following the path of Route 66, Interstate 40 offers a compelling and essential journey across the American landscape.